(stockholm June 29, 2022) A new paper in the Journal of Environmental Science and Pollution Research explores the effects of inhaling, versus ingesting, PFOA (perfluoro-octanic acid), in household dust. PFOA is a common toxic substance found in industries and households around the world. In the study, carried out at Institute of Environmental Medicine at Karolinska InstitutePreciseInhale acreached a standard deviation of 10-15% and demonstrated that the concentration of PFOA was four times higher by inhalation than by ingestion – a new result not previously published.
Perfluoro-octanic acid (PFOA) is an industrial surfactant used in industries, chemical processes and households around the world. It is commonly found in carpets, upholstery, clothing, floor wax, sealants, textiles and many more. Concerns and research on the toxicity of PFOA are long established, with the substance considered a possible carcinogen, toxic to the liver, and toxic to the immune system (1).
Now, in a new study conducted at KI Institute of Environmental Medicine, scientists explored the effects on rats of PFOA in house dust when inhaled or ingested. To expose the rats, the scientists chose to use the single animal from both ISAB live intubation method: “A relevant inhalation exposure condition was established using the PreciseInhale system, where intubated rats spontaneously inhaled house dust.”
Unlike conventional “tower test” technologies, ISAB’s intubation method delivers aerosol directly into the lungs of individual test rodents, bypassing the nose, while carefully monitoring aerosol concentration and patterns. individual respiratory. The result is exceptionally accurate data.
In this study, the accuracy of the PreciseInhale results was indeed high – with a standard deviation of 10-15% in all exposed subjects. In new unpublished results, PreciseInhale also found that the blood concentration of PFOA in rats was four times higher when inhaled than when ingested after exposure to the same levels of dust. This is a very socially relevant result demonstrating that inhalation is an effective exposure channel for pollutants like PFOA both at home and at work.
Manoush Masarrat, CEO of ISAB: “These precise, revealing and important results show how much inhalation science can offer research on environmental medicine and air pollution. The unique accuracy and precision offered by PreciseInhale in this case really allowed scientists to reach a higher level of understanding aerosol data.”
The publication is titled “Bioavailability of inhaled or ingested PFOA adsorbed on house dust”. Read the post here.
Its authors are: Åsa Gustafsson and bei wang (MTM Research Center, School of Science and TechnologyÖrebro University) Per Gerde (Institute of Environmental Medicine, Karolinska Institute and Inhalation Sciences AB) and Åke Bergman and Leo WY Yeung (Department of Environmental Sciences, Stockholm University.)
For more information on Inhalation Science, please contact:
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About Inhalation Sciences Sweden AB (publication)
Inhalation Sciences Sweden AB (publ) develops and markets state-of-the-art instruments and services for inhalation research. The company’s patented lab instruments, PreciseInhale® and DissolvIt®, enable researchers in the pharmaceutical industry to make drug pipeline decisions at an early stage, saving R&D departments time and resources, and allows researchers at academic institutions to define the impact of aerosols and small particles on our lungs. , and therefore our health, when inhaled.
(c) Decision 2022. All rights reserved., sources Press Releases – English